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Inside a lab at the Massachusetts Institute of Technology late last year, scientists gave an AI system a new task: designing entirely new molecules for potential antibiotics from scratch. Within a day or two—following a few months of training—the algorithms had generated more than 29 million new molecules, unlike any that existed before. Traditional drug discovery is a slow, painstaking process. But AI is beginning to transform it. At MIT, the research is aimed at the growing challenge of antibiotic-resistant infections, which kill more than a million people globally each year. Existing antibiotics haven’t kept up with the threat. “The number of resistant bacteria…

New York City is a city of walkers. More trips are made on foot than by car (41% versus 28%) and the city’s “80X50” climate action plan envisions that 80% of all trips by 2050 will be made either on foot, by biking, or by public transit. The problem is that pedestrian movement in the city has remained largely unmapped and underestimated—until now. Together with a team of researchers, Andres Sevtsuk, an associate professor in MIT’s Department of Urban Studies and Planning, has built what he says is the first complete model of pedestrian activity in New York City—and it’s a model that can now be applied to any U.S. city. The model, which maps foot traffic across al…

A new study from MIT that shows that AI might be poised to replace a lot more jobs than what initial estimates might predict. According to researchers, a hidden mass of data reveals that AI is currently capable of taking over 11.7% of the labor market. The new estimate comes courtesy of a project called The Iceberg Index, which was made through a partnership between MIT and Oak Ridge National Laboratory (ORNL), a federally funded research center in Tennessee. According to its website, the Iceberg Index “simulates an agentic U.S.—a human-AI workforce where 151M+ human workers coordinate with thousands of AI agents.” In simpler terms, the tool is designed to simulate pr…

Mixed nuts are a common staple in many houses around the Christmas holidays. Their saltiness is a nice contrast to all the sweet festive treats that our kitchens fill up with at this time of year. But now the Food and Drug Administration (FDA) has warned that two mixed nut products have the potential to make you very sick. Here’s what you need to know. FDA announced mixed nuts recall On December 5, the Food and Drug Administration posted a notice announcing the recall of two mixed nuts products. The nuts were sold under the Wegmans brand. Wegmans is a popular chain of grocery stores in the eastern United States. The nuts were manufactured by Mellace Family…

Cleveland Guardians pitchers Emmanuel Clase and Luis Ortiz have been indicted on charges they took bribes from sports bettors to throw certain types of pitches, including tossing balls in the dirt instead of strikes, to ensure successful bets. According to the indictment unsealed Sunday in federal court in Brooklyn, the highly paid hurlers took several thousand dollars in payoffs to help two unnamed gamblers from their native Dominican Republic win at least $460,000 on in-game prop bets on the speed and outcome of certain pitches. Clase, the Guardians’ former closer, and Ortiz, a starter, have been on non-disciplinary paid leave since July, when MLB started investigatin…

A computerized system that calls balls and strikes is being tested during Major League Baseball spring training exhibition games starting Thursday after four years of experiments in the minor leagues. Baseball Commissioner Rob Manfred is an advocate of the Automated Ball-Strike System, which potentially as early as 2026 could be used to aid MLB home plate umpires, but not replace them. Starting in 2024, MLB focused testing on a challenge system in which the human umpire makes each original call. Data from the spring training test could cause MLB to make alterations to the system for Triple-A games this season. How does the Automated Ball-Strike System work? …

Major League Baseball said its authorized gaming operators will cap bets on individual pitches at $200 and exclude them from parlays, a day after two Cleveland Guardians were indicted and accused of rigging pitches at the behest of gamblers. MLB said Monday the limits were agreed to by sportsbook operators representing more than 98% of the U.S. betting market. The league said in a statement that pitch-level bets on outcomes of pitch velocity and of balls and strikes “present heightened integrity risks because they focus on one-off events that can be determined by a single player and can be inconsequential to the outcome of the game.” “The risk on these pitch-level marke…

Update Thursday, 2:13 p.m.: MNTN Inc, the advertising technology company that counts Hollywood actor Ryan Reynolds as its chief creative officer, made its market debut on Thursday, in a closely watched initial public offering (IPO) that is testing investor appetite for the rapidly growing segment of ad-supported streaming television. Shares in the Austin-based company were up more than 14% in midday trading to over $24, after opening at $21. On Wednesday, the stock was priced at $16 a share, the higher end of the company’s expected range, in an offering led by Morgan Stanley, Citigroup, and Evercore ISI. The stock listed on the New York Stock Exchange (NYSE) under…

MNTN Inc, the advertising technology company that counts Hollywood actor Ryan Reynolds as its chief creative officer, is expected to make its market debut on Thursday, in a closely watched initial public offering (IPO) that will test investor appetite for the rapidly growing segment of ad-supported streaming television. The Austin-based company priced shares at $16 on Wednesday, the higher end of its expected range, in an offering led by Morgan Stanley, Citigroup, and Evercore ISI. The stock will list on the New York Stock Exchange (NYSE) under the “MNTN” ticker symbol. Based on its IPO share price, MNTN—it’s pronounced Mountain—has an approximate valuation of $…

The Fast Company Impact Council is an invitation-only membership community of leaders, experts, executives, and entrepreneurs who share their insights with our audience. Members pay annual dues for access to peer learning, thought leadership opportunities, events and more. Late for a meeting across town, you check a map app for the fastest route, toggle to the city’s transit site for schedules, and work out options for traveling the “last mile” from the train station to your destination. You think through the logistics—metro card, e-tickets, scanning app, method of payment—for each leg of the trip. Then you open a ride-hailing app as backup. MaaS: Cities slic…

The rise of OpenClaw, a proactive agentic AI controlled through interfaces more familiar to the average user than tools like Anthropic’s Claude Code, which enthralled early adopters over the holiday period, has been one of the most seismic shifts in the AI world since the release of ChatGPT. By piggybacking on user-friendly interfaces paired with powerful AI agent technology, OpenClaw has pushed AI further into the public eye. Thousands have spun up their own AI agents using the tech, and many of those agents have ended up on Moltbook, a social network where AI agents can post and interact with one another. The platform, which looks a lot like Reddit, was developed by…

In early February, the AI world found itself worked up over Moltbook, a social platform for AI agents to communicate and interact. These AI agents allegedly created their own language, their own religion, their own fleets of mini-agents. It’s like The Matrix was happening in front of our eyes. What a boondoggle. I say “allegedly” because it turns out many of these agents were being directed by humans, among other Mechanical Turk-style fakeries. Moltbook is worth a conversation, for sure, but not the one taking place. Here’s how we should really be thinking about it. TOKEN CARNAGE Running AI infrastructure costs are astronomical. Back in 2023, it was est…

Paola Antonelli has a litmus test for worthy design. People often ask the Museum of Modern Art’s senior curator of architecture and design how she decides what to add to the museum’s collection, and she gives them simple instructions: “Close your eyes and think, If this object did not exist, would the world miss out?” she says. Of course, filling one of the world’s preeminent art museums is not quite that easy. Antontelli says you also have to consider an object’s form, function, and problem-solving utility—but her litmus test is something she returns to again and again. “It doesn’t mean that something has to be necessary,” Antonelli clarifies. Take, for example, the …

I will never forget the day I realized how rare it is to see businesses support parents—or what a huge impact even the tiniest efforts can make. “We’re just going to run into the store for a few quick things!” I called to my two kids with confidence as I unloaded them from the car, skipping the bulky stroller and putting my 1-year-old in the shopping cart seat. But what should have been a simple trip took a turn when we unexpectedly needed to visit the restroom. As any mom knows, this is where things can start to unravel: You can’t take the cart inside, so what are you supposed to do with your not-yet-walking child while you help the bigger one use the toilet? A…

I’ve worked for myself for nearly a decade, and in all but one of those years I’ve earned more than the U.K. average salary. Some years it’s been a little more. I’m naturally frugal, and even during the rockiest stretches, there’s always been enough to cover the basics—plus a safety net if I ever truly needed it. Yet I worry about money constantly, gnawed by the sense that I’m only one missed invoice from financial collapse. Although I’m generally wary of self-diagnosis, the term “money dysmorphia”—a disconnect between how we feel about our finances and the reality—fits me like a glove. From the rise of HENRYs (“high earners, not rich yet”) to the boom in “income …

Shortly after 7:00 local time this morning, the internet-famous walk for peace monks began the final miles of their 2,300-mile walking journey. They left Alexandria, Virginia, and are set to arrive in Washington, D.C., before 9:30 a.m., where they’ll take part in a public event at Bender Arena. The group plans to spend the next three days in and around the nation’s capital before traveling by bus to Fort Worth, Texas, where the journey began. Find out how they plan to spend the next few days. Who are the monks and why did they walk to D.C.? More than three months ago, a group of about 19 Buddhist monks and their rescue dog companion, Aloka, set out on a …

A group of about 19 Buddhist monks and their rescue dog, Aloka, are walking from Fort Worth, Texas, to Washington, D.C., to promote world peace. Their planned route spans approximately 2,300 miles across 10 states and is expected to take 120 days to complete. Here’s what to know about their journey and how to follow along in real time: Why are the monks walking? The group has been sharing updates about their journey on their official Walk for Peace Facebook page. According to the Facebook page, the walk is intended to promote the “awareness of peace, loving kindness, and compassion across America and the world.”​ Their movement has drawn massive support …

Now you can sing along with America’s Founding Fathers as you crush your opponents under oppressive rents and market domination. The Op Games, a publisher of board games and puzzles, is releasing a new version of Monopoly based on the hit Broadway musical Hamilton, marking the latest iteration of the classic economics game that has been a staple of family game nights for many decades. The Op Games plans to announce the new version today, a spokesperson told Fast Company. The game commemorates the 10th anniversary of Lin-Manuel Miranda’s rap-infused retelling of America’s origin story, which made its Broadway debut in the summer of 2015 and went on to win 11 To…

Want more housing market stories from Lance Lambert’s ResiClub in your inbox? Subscribe to the ResiClub newsletter. When I recently reached out to Moody’s Analytics chief economist Mark Zandi for his updated home price forecast, he said his long-term outlook for the U.S. housing market remains largely unchanged: he expects a prolonged period of stagnation as affordability gradually improves. Following the historic run-up in prices during the Pandemic Housing Boom and the subsequent mortgage rate shock, Zandi believes resale activity/existing home sales will likely stay frozen for several more years. “Affordability has to be restored for housing to regain its m…

A well-funded AI lab with a deep bench of research talent is releasing a powerful new model that generates high-definition video for the film and advertising industries. The company, Moonvalley, on Wednesday launched its first model, named Marey—a nod to early cinema pioneer Étienne-Jules Marey—which could soon help Hollywood studios dramatically speed up production and cut costs. What sets Marey apart—and has caught the attention of risk-averse studios—is its training data. The model was trained exclusively on video content either owned or fairly licensed by Moonvalley, avoiding the copyright gray zones that make much generative content legally fraught. Moonvalle…

Americans are seeking financial relief and, in some cases, are even desperate enough to go against conventional financial wisdom. A record number of Americans are turning to their retirement funds to cover emergency expenses. According to newly released data from Vanguard, 6% of 401(k) holders took hardship withdrawals last year. The number is up from 4.8% in 2024, and well above prepandemic levels of about 2%. Taking funds out early is not recommended because early withdrawals from 401(k) plans are taxed. In addition, the funds incur a 10% penalty if the person withdrawing them is under the age of 59½. (The IRS does allow some exceptions to the penalty, includin…

Single this Valentine’s Day? You’re not alone. New research from The Harris Poll shows that nearly half of Americans (46%) are not in relationships—many of them on purpose. The report, shared exclusively with Fast Company, calls it a “cultural revolution,” where people are using singlehood as a way to prioritize their agency rather than focusing on traditional relationship expectations. Not everyone is staying single, but 80% of Americans say you don’t need marriage to be happy. In fact, singles are more likely than those in relationships to say they live a fulfilling life. More time for friendships—or careers The idea of what makes a fulfilling relationsh…

Almost half of Americans have considered or plan to move abroad to improve their happiness, according to a Harris poll published today. Specifically, the poll found that four in 10 Americans have at least thought about leaving the country within the next few years. And among Gen Z and millennials, almost one in five respondents reported “seriously considering” an imminent move. The results show that Americans are becoming increasingly disillusioned with the “American Dream” as the cost of essentials like rent, healthcare, and education continues to rise. Here are three main takeaways from the poll: Home ownership and cost of living are top of mind Per…