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The biggest story in tech is AI’s increasing capacity to take on tasks once reserved for human beings. But the agents driving that change aren’t machines. They’re humans—inventive, ambitious, enterprising ones. Our third annual roundup of some of the field’s most intriguing players includes scientists and ethicists, CEOs and investors, big-tech veterans and first-time founders. These 20 innovators are tackling challenges from training tomorrow’s AI models to speeding drug discovery to reimagining everyday productivity tools. Household names they’re not. Yet, they’re already changing our world, with much more to come.


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Oriana Fenwick

Michelle Pokrass

Technical Staff Member, OpenAI

Last year, OpenAI decided it had to pay more attention to its power users, the ones with a knack for discovering new uses for AI: doctors, scientists, and coders, along with companies building their own software around OpenAI’s API. And so the company turned to post-training research lead Michelle Pokrass.


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Rachel Taylor

Product Manager, Sesame

Rachel Taylor began her career as a creative director in the advertising business, a job that gave her plenty of opportunity to micromanage the final product. “I had control of the script,” she remembers. “I could think about the intonation, and I could give the actor notes.”


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Naeem Talukdar

Cofounder and CEO, Moonvalley

The rise of AI-generated actress Tilly Norwood may have been a stunt, but Hollywood is indeed embracing generative AI, a threat to those who owe their livelihoods to the movies. Still, AI could also expand a filmmaker’s creative vision by creating ambitious scenes or effects too pricey to shoot, says Naeem Talukdar, CEO of the video-generation model developer Moonvalley.

“Every project you see on the big screen is a result of an endless amount of creative compromises from the directors and the filmmakers,” he says.

Moonvalley, which has raised $154 million, works with four of Hollywood’s biggest studios, advising them on how to integrate AI into productions and reskill workers. Its model is trained on licensed, high-resolution content and is capable of production-grade video generation.

Over the past year, Moonvalley has shifted its focus to developing “world models,” which generate video that accurately portrays the complex physics of something like a car crash. As these models grow, says Talukdar, “they start to be able to reason on things that they haven’t seen before.” —Mark Sullivan


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Koray Kavukcuoglu

Chief AI Architect, Google

For years, Google has employed many of AI’s brightest minds. Yet it was burdened with a reputation for ineffectiveness when it came to turning its breakthroughs into products. Recently, however, CEO Sundar Pichai has made dramatic moves to overcome that unfortunate legacy. A big one came in June 2025 when he named Koray Kavukcuoglu the company’s first chief AI architect.

A onetime Google summer intern and veteran of DeepMind, the British AI startup Google acquired in 2014, Kavukcuoglu helped manage the 2023 merger of DeepMind and Google Brain, another research arm. He remains CTO of the combined entity, Google DeepMind, but now he reports directly to Pichai, who announced the promotion in a memo explaining that Kavukcuoglu’s new role would bring “more seamless integration, faster iteration, and greater efficiency” to Google’s lab-to-market pipeline. Hundreds of staffers working to apply Google’s Gemini large language model to transform its search engine are now part of his team, The Information reported. He’s also involved with everything from data center strategy to bolstering the Google Cloud web services platform.

Kavukcuoglu’s background is in the science of AI, not turning it into offerings that appeal to billions of people. Still, as Gemini-powered features increasingly show up in Google mainstays such as search, Android, and Gmail, investors have grown more optimistic that Google will be a titan of the AI era rather than a victim of it. As the company strives to keep that momentum going, Kavukcuoglu’s deep familiarity with its technical stack should be an asset. “There’s a long history of research that built up to this point,” he told Big Technology’s Alex Kantrowitz last May. —Harry McCracken


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Justine and Olivia Moore

Partners, Andreessen Horowitz

Andreessen Horowitz investors (and identical twins) Justine and Olivia Moore have been in venture capital since their days at Stanford University, where, in 2015, they cofounded an incubator to help students pursue business ideas.


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Byron Cook

VP and Distinguished Scientist, Amazon

Hallucinations are baked into the way generative AI works, but that doesn’t mean we have to live with them. Byron Cook—a vice president and distinguished scientist at Amazon Web Services—realized that an alternative AI technology called “automated reasoning” could be the perfect way to keep chatbots’ confabulations in check.

The product he spearheaded in 2024, called Automated Reasoning Checks, acts like Mr. Spock for language models, using rigid logic to catch and correct up to 99% of hallucinations.

Now Cook is applying automated reasoning to agents: autonomous, LLM-powered enterprise apps. Many businesses don’t trust them—yet. “First of all, this [agent] could lie to me,” explains Cook. “But secondly, if I let it launch rockets”—his metaphor for irreversible actions—“will it launch rockets when we’re not supposed to?”

Amazon is betting that automated reasoning, and Cook, can keep agents on a leash. —John Pavlus


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Shiv Rao

Cofounder and CEO, Abridge

A cardiologist at the University of Pittsburgh Medical Center (UPMC), Shiv Rao is the cofounder of Abridge, an AI-driven platform that records doctor–patient conversations in real time. The AI works across more than 100 languages and can distinguish when a doctor, patient, or translator is speaking to make the most accurate records.

Abridge is also integrated into medical platforms such as Athenahealth and Wolters Kluwer, where it can fill out forms and expedite tasks like insurance pre-authorization or writing prescriptions.

Rao, who has experience as a tech investor with UPMC, developed the idea while making his rounds. His hospital’s proximity to Carnegie Mellon, a tech hub, gave him a firsthand look at machine learning. That led him to found his company in 2018, long before ChatGPT came around. Abridge, which has raised a total of approximately $800 million, is currently in use at more than 150 U.S. health systems, including Johns Hopkins Medicine, the Mayo Clinic, Kaiser Permanente, and Duke Health. The less time physicians spend on paperwork, the more time they have to focus on their patients.

“As a doctor, I’m not compensated for the care that I deliver—I’m compensated for the care that I documented that I deliver,” Rao says. “So we are extending the documentation to help with billing.” —Yasmin Gagne


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Oriana Fenwick

Kyle Fish

Research Scientist, Anthropic

What if the chatbots we talk to every day actually felt something? What if the systems writing essays, solving problems, and planning tasks had preferences, or even something resembling suffering? And what will happen if we ignore these possibilities? Those are the questions Kyle Fish is wrestling with as Anthropic’s first in-house AI welfare researcher.


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Kanjun Qiu

Cofounder and CEO, Imbue

Before most people started thinking about generative AI, Imbue cofounder and CEO Kanjun Qiu was worrying about its future. Qiu had established a co-living community in San Francisco called the Archive, where she counted among her housemates several working in AI, providing her with an early sense of how AI might further consolidate power among the big tech companies.

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“There’s this growing sense that both digital technology and AI are happening to people, they’re not necessarily happening with us or for us,” she says.

Imbue, which emerged from stealth in late 2022, aims to help people create their own AI tools. It’s working on an AI-assisted software development tool called Sculptor, which became open to public preview in late September.

“What we’re trying to do is create a tool that lets you feel the structure of your software and understand it,” says Qiu, by enabling it to remember context across different projects and suggesting ways to refine users’ code. While other AI software development startups such as Bolt and Replit offer stand-alone products, Sculptor acts as an interface for Claude Code, allowing developers to run multiple agents in parallel. —Jared Newman


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Paula Goldman

Chief Ethical and Humane Use Officer, Salesforce

Before Paula Goldman became Salesforce’s first in-house ethicist in 2019, she earned a PhD in anthropology at Harvard. That training remains central to her work at the business software giant, which now includes helping product teams set guardrails for AI behavior, testing tools for safety, and engaging policymakers on trustworthy AI.

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Goldman had already been immersed in these questions at eBay founder Pierre Omidyar’s impact investment firm, where she evaluated the social consequences of emerging technology. Goldman is now helping refine Salesforce’s ethical principles around the deployment and testing of generative AI and agentic tools. Her team has helped develop systems to ensure AI follows instructions, avoids toxic behavior, and stays within established ethical guidelines.

“Those types of tools are increasingly important as AI takes on more autonomy,” she says. “You want to make sure that the person that’s setting up the system is able to see in advance what it’s going to produce.”

But while cloud technology has continued to evolve, Goldman says one thing has not: establishing trust with customers. “Obviously, we are a business, and being commercially successful is very important,” she says. “Also, we know that trust is what makes that possible.” —Steven Melendez


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Tara Feener

Head of Engineering, the Browser Company

You might not spend a lot of time thinking about your web browser. But the decades-old app remains an important canvas for getting things done. That’s why Tara Feener, who spent years developing creative tools at the likes of Adobe and Vimeo, joined the Browser Company. Within two years, she was head of engineering for its AI-forward Dia browser.


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Dean Ball

Senior Fellow, Foundation for American Innovation

In Washington’s scramble to govern artificial intelligence, few have had as much influence as Dean Ball. A former research fellow at the Mercatus Center, a libertarian think tank, Ball was the principal author of the AI Action Plan, which the White House released in July.

Depending on whom you ask, the document will either secure the United States’ lead in AI or unleash reckless proliferation.

The plan focuses on accelerating innovation through deregulation, streamlining the construction of data centers, and driving the adoption of American-made AI tools abroad. It includes popular provisions like embracing open-source AI, along with divisive ones such as requiring federal agencies to work only with LLM developers whose AI models are “free from top-down ideological bias” and withholding AI funding from states that pass AI laws the administration deems burdensome.

Even as the industry has praised the document, critics have panned it for failing to curb AI’s potential harms, such as discriminatory system biases. But avoiding assumptions about AI’s future is the point, says Ball, who left the White House in August and is now a fellow at the conservative Foundation for American Innovation. “Washington’s really bad at forecasting how technology will develop,” he says. “We don’t want to make those mistakes.” —Issie Lapowsky


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Oriana Fenwick

Raquel Urtasun

Founder and CEO, Waabi

After decades of AI research, Waabi CEO Raquel Urtasun believes she has learned how to build a better self-driving truck. Urtasun began her career in academic research about 25 years ago, focusing much of it on autonomous-driving technologies such as object detection. “There was a lot of innovation that needed to happen in order to enable the revolution that we see today,” she says.

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Following a stint as chief scientist at Uber’s self-driving car unit, Urtasun launched Waabi in 2021 to build a verifiable, human-interpretable AI model for autonomous driving. Waabi-enabled big rigs have been on public roads since 2023 and are slated for driverless operation by the end of 2025. Though many autonomous truck systems are limited to highways and depots, Waabi’s technology is designed to carry goods all the way to their final destinations on surface streets. The company has raised more than $280 million to date.

Urtasun also remains a computer science professor at the University of Toronto, where her graduate students conduct doctoral research at Waabi through a unique arrangement. Some recent research involves simulation, allowing Waabi to now let its AI practice in situations it’s never encountered in the physical world—a key advantage for its system.

Waabi’s AI has shown that it can quickly react to novel conditions, even seamlessly managing its first encounter with rain, which it had never practiced for. “It was kind of nerve-racking,” says Urtasun, who was in that vehicle with some investors. “But it was amazing to see.” —Steven Melendez


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Karrie Karahalios

Professor, MIT Media Lab

For years, the feeds on Facebook, Instagram, and TikTok have devoured our attention. Mediated by opaque algorithms, they reduce users to passive consumers of content whose likes and shares tell the platform how to keep them scrolling and viewing ads. Karrie Karahalios is well-known for her research on the fairness of these social algorithms, studying their inputs and outputs.

Since joining the MIT Media Lab in September, she has been expanding her research into ways of empowering individuals and communities to fight back against algorithmic overreach. This has led her to focus on “contestable systems,” which let human users “talk back” to algorithms, perhaps to contest a content moderation decision that may at first seem final. This could be through a set of preference settings to control the content of a social feed, or it might be through an AI voice or chat interface that allows a user to engage the algorithm in a plain language dialogue. If no solution is reached, the issue might be bumped up to a human moderator.

“As we build these systems, and they seem to be permeating our society right now, one of my big goals is not to ignore human intuition and not to have people give up agency,” Karahalios says. —Mark Sullivan


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Rodrigo Liang

Cofounder and CEO, SambaNova Systems

Why aren’t more chips designed to reduce the huge amount of power used by AI data centers? Rodrigo Liang, SambaNova’s cofounder and CEO, compares traditional GPUs to a cook that prepares each dish individually. SambaNova’s Reconfigurable Dataflow Units (RDUs), in contrast, operate like an assembly line that processes each part of an AI request in sequence.

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RDUs compete with traditional GPUs for AI inference—the application of trained models to new data that happens when we use AI apps. The goal: to slash inference power requirements, while also reducing latency. Customers with strict privacy requirements can run servers with SambaNova’s RDUs on site, or they can have the company manage them in the cloud. “We found it hard to believe that we had to rely on an architecture that was started 25 years ago, 30 years ago, and primarily focused on graphics and gaming,” Liang says.

SambaNova raised $676 million at a $5.1 billion valuation in April 2021, yet challenges remain, most notably the dominance and mindshare of large players such as Nvidia. Still, Liang believes SambaNova’s advantages will accrue with AI’s increasing power and performance demands. “All the things that we’ve designed natively into the product are going to become more and more important,” he says. —Jared Newman


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David Kossnick

Senior Director and Head of AI Products, Figma

Before David Kossnick joined Figma, he was one of the design platform’s millions of users and full of ideas for improving it. In March 2024, he was named to oversee the company’s AI products—a key element of its growth strategy after its August 2025 IPO—offering him the chance to do more than daydream about its future.

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The fruits of Kossnick’s labor are more and more apparent. AI features now span Figma’s portfolio, from its flagship Design app to the new Make vibe coding tool to features for creating slideshows, websites, and marketing assets. Given Figma’s inherently multidisciplinary nature—two-thirds of its users work in areas outside design—the technology can knock down some of creativity’s traditional boundaries, he asserts: “It’s easier with the help of AI to reach into a lane where you’re not as familiar with the details and bring the context, the intuition, the insight that you have.”

At the same time, the company has been careful not to mess up elements of its experiences that people liked in the first place—which means that some of its best AI is nearly invisible, at least until users know they want it. “Figma Design’s canvas is kind of like the Google homepage or Facebook newsfeed,” says Kossnick. “A single pixel of friction literally slows down millions of people every day.” —Harry McCracken


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Oriana Fenwick

Kimberly Powell

VP of Healthcare, Nvidia

Bringing new drugs to market requires decade-long, multibillion-dollar journeys, with a high failure rate in the clinical trial phase. Nvidia’s Kimberly Powell is at the center of a major effort to apply AI to the challenge. “If you look at the history of drug discovery, we’ve been kind of circling around the same targets for a long time, and we’ve largely exhausted the drugs for those targets,” she says.


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Sonia Kastner

Cofounder and CEO, Pano AI

From mountaintop perches across 13 states, Pano AI’s cameras scan the horizon, searching for wisps of smoke that humans might overlook for hours. “Today’s fires are spreading much more quickly,” says CEO Sonia Kastner, who cofounded Pano AI in 2020. “You don’t have time for slow detection, slow assessment, slow buildup of resources.”

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Pano’s system detects wildfires in a median of 3.5 minutes—revolutionary compared with traditional 911 alert times. It triangulates fire locations within hundreds of meters and alerts multiple agencies at once.

Kastner’s eight-person AI team has spent five years training models to spot fires and distinguish smoke from dust or clouds. “Quietly, computer vision has gotten really, really good,” she says. While enterprises (and more and more states) have embraced the system—the company has secured more than $140 million in cumulative contracts and raised a $44 million funding round in June—federal adoption remains the biggest hurdle. To that end, Kastner frequently travels to Washington to push agencies to modernize procurement. “We’re serving as a bridge between the technology sector and emergency managers on the front lines of these ever-worsening natural disasters,” she says. —Jeremy Caplan


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Jonathan Siddharth

Cofounder and CEO, Turing

In early 2023, Jonathan Siddharth foresaw the coming AI arms race. He expanded the mission of his company, Turing, a recruiting platform that matched companies with remote workers. “We went from finding smart software engineers to finding smart humans in every field and building a platform that could extract that human knowledge and skills and distill it into an LLM,” he says.

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Today, Turing supplies training data for eight of the nine companies developing the largest general-purpose AI models. The shift has also turned Turing into a quiet but central player in the artificial intelligence ecosystem, shaping what the next generation of AI systems will know. Turing is profitable and valued at roughly $2.2 billion.

As models have advanced, generic data (often scraped from the web) is no longer good enough to achieve further intelligence gains. AI researchers need a regular supply of data that captures deep subject-matter expertise across domains from STEM to healthcare, Siddharth says. “We’re able to do that because we have two engines: the talent engine that’s finding smart talent and the data generation platform that the talent works on.” —Mark Sullivan


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