If you’re selling special products to a regulated industry (e.g., medical devices or holistic health care supplements), you’ll need to check with your state to see if you need to be licensed to provide those kinds of products or services. But generally, the sale of digital information, clothing, or handcrafted items (made in the USA) doesn't require a special business license. Rather, the business licensing required for an online retail business is not substantially different than that of a storefront business:
You will want to form a business entity in your state.
You will want